Hadiah Nobel Kimia 2024



Ditulis oleh Danielle Niemann, Mike Corder, dan Christina Larson

STOCKHOLM (AP) — Tiga ilmuwan yang telah menemukan teknik ampuh untuk memprediksi dan bahkan merancang protein baru – bahan penyusun kehidupan – dianugerahi Hadiah Nobel Kimia pada hari Rabu. Pekerjaan mereka menggunakan teknik-teknik canggih, termasuk pembelajaran mesin, dan memiliki potensi untuk mengubah cara pembuatan obat-obatan baru.

Penghargaan tersebut diberikan kepada David Becker, yang bekerja di University of Washington di Seattle, serta Demis Hassabis dan John Jumper, yang bekerja di Google DeepMind, sebuah laboratorium penelitian kecerdasan buatan Inggris-Amerika yang berbasis di London.

Heiner Linke, Ketua Komite Nobel Kimia, mengatakan bahwa penghargaan ini menghormati penelitian yang telah mengungkap rahasia ilmiah yang telah lama ada.

“Ini sebenarnya disebut sebagai tantangan besar dalam bidang kimia, khususnya biokimia, selama beberapa dekade. Jadi, inilah terobosan yang kita miliki saat ini.”

Apa Hadiah Nobel Kimia?

Protein adalah molekul kompleks yang mengandung ribuan atom yang memelintir, memutar, memelintir, dan memelintir menjadi berbagai bentuk yang tak terbatas. Bentuk protein menentukan fungsi biologisnya. Selama beberapa dekade, para ilmuwan memimpikan kemampuan merancang dan membangun protein baru secara efisien.

Becker, yang karyanya mendapat dana dari National Institutes of Health sejak tahun 1990-an, menciptakan program komputer bernama Rosetta yang membantu mengurai informasi tentang protein yang ditemukan dalam database komprehensif untuk membangun protein baru yang tidak ditemukan di alam.

“Tampaknya sekarang Anda dapat membuat hampir semua jenis protein dengan menggunakan teknologi ini,” kata Johan Akvist dari Komite Nobel.

Komite menambahkan bahwa Hassabis dan Jumper menciptakan model kecerdasan buatan yang mampu memprediksi struktur sekitar 200 juta protein yang diidentifikasi oleh para peneliti.

Duo ini “berhasil memecahkan kodenya. “Melalui penggunaan kecerdasan buatan yang terampil, struktur kompleks protein apa pun yang dikenal di alam dapat diprediksi,” kata Linke.

Mengapa pekerjaan ini penting?

Kemampuan untuk merancang protein baru secara khusus – dan lebih memahami protein yang sudah ada – dapat memungkinkan para peneliti menciptakan jenis obat dan vaksin baru. Hal ini juga memungkinkan para ilmuwan merancang enzim baru untuk memecah plastik atau bahan limbah lainnya, dan merancang sensor yang tepat untuk bahan berbahaya.

“Saya pikir ada prospek besar untuk membuat obat yang lebih baik, obat yang lebih cerdas, yang hanya bekerja pada waktu dan tempat yang tepat di dalam tubuh,” kata Baker kepada Associated Press.



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